@article{ref1,
title="Neurogenesis in Adult Human Brain after Traumatic Brain Injury",
journal="Journal of neurotrauma",
year="2013",
author="Zheng, Weiming and Zhuge, Qichuan and Zhong, Ming and Chen, Gourong and Shao, Bei and Wang, Hong and Mao, Xiaoou and Xie, Lin and Jin, Kunlin",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="While much work has been conducted regarding the neurogenesis response to traumatic brain injury (TBI) in rodents, it remains largely unknown whether neurogenesis in adult human brain also responds to TBI in a similar manner. Here, we performed immunocytochemistry on eleven brain specimens from patients with traumatic brain injury, who underwent surgical intervention. We found that expression of neural stem/progenitor cell (NSC) protein markers including DCX, TUC4, PSA-NCAM, SOX2 and NeuroD were increased in the perilesional cortex of human brain after TBI, compared to normal brain. Confocal images showed that these NSC proteins were expressed in one single cell. We also found that proliferative markers were expressed in NSC protein-positive cells after TBI, and the number of proliferative NSCs was significantly increased after TBI. Our data suggest that TBI may also induce neurogenesis in human brain.<p /> <p>Language: en</p>",
language="en",
issn="0897-7151",
doi="10.1089/neu.2010.1579",
url="http://dx.doi.org/10.1089/neu.2010.1579"
}