@article{ref1,
title="Exploring the relationship between vitamin D and basic personality traits",
journal="Psychopharmacology",
year="2011",
author="Ubbenhorst, Andrea and Striebich, Sarah and Lang, Florian and Lang, Undine E.",
volume="215",
number="4",
pages="733-737",
abstract="RATIONALE: Several studies suggest an association between hypovitaminosis D and basic and executive cognitive functions, depression, bipolar disorder, and schizophrenia. A recent study confirms neophobic responses in vitamin D receptor mutant mice. We explored whether the plasma levels of 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)), the active form of vitamin D, are correlated with basic personality traits. METHODS: A total of 206 healthy unrelated volunteers (108 male, 98 female, age 31 ± 13 years) completed the German version of the NEO Five-Factor Inventory (NEO-FFI), which allows reliable and valid assessment of personality along the dimensions neuroticism, extraversion, openness to new experiences, agreeableness and conscientiousness. RESULTS: We found a significant correlation between 1,25(OH)(2)D(3) concentration and the factor extraversion (n = 206, r = 0.202, p = 0.004) and the factor openness (n = 206, r = 0.148, p = 0.034). CONCLUSION: The possible mechanisms by which 1,25(OH)(2)D(3) acts on the brain might include Ca(2+) signaling, buffering antioxidant, and anti-inflammatory defenses against vascular injury, stimulating neurotrophins and improving metabolic and cardiovascular function. In conclusion, we suggest that 1,25(OH)(2)D(3) might influence personality traits, promoting extrovert and open behavior.<p /> <p>Language: en</p>",
language="en",
issn="0033-3158",
doi="10.1007/s00213-011-2175-x",
url="http://dx.doi.org/10.1007/s00213-011-2175-x"
}