@article{ref1,
title="Reversal sign on CT: effect of anoxic/ischemic cerebral injury in children",
journal="AJR American journal of roentgenology",
year="1990",
author="Han, B. K. and Towbin, R. B. and De Courten-Myers, G. and McLaurin, R. L. and Ball, W. S.",
volume="154",
number="2",
pages="361-368",
abstract="A retrospective study was performed to determine the clinical and pathologic features, etiology, and outcome of children with the reversal sign. The reversal sign, a striking CT finding, probably represents a diffuse, anoxic/ischemic cerebral injury. CT features of the reversal sign are diffusely decreased density of cerebral cortical gray and white matter with a decreased or lost gray/white matter interface, or reversal of the gray/white matter densities and relatively increased density of the thalami, brainstem, and cerebellum. Twenty children with the reversal sign were retrospectively analyzed. We divided the patients into three groups: (1) acute reversal, (2) intermediate group, and (3) chronic reversal. There were nine cases of trauma (seven of child abuse); nine hypoxia/anoxia incidents (birth asphyxia, drowning, status epilepticus); one bacterial meningitis; and one degenerative encephalitis. All acute- and intermediate-group patients had respiratory problems requiring ventilator support and intensive care. In five of seven patients who died, autopsy findings were consistent with anoxic/ischemic encephalopathy. Surviving patients have profound neurologic deficits with severe developmental delay. The CT reversal sign carries a poor prognosis and indicates irreversible brain damage.<p /><p>Language: en</p>",
language="en",
issn="0361-803X",
doi="",
url="http://dx.doi.org/"
}