@article{ref1,
title="Aggressive behavior in male mice lacking the gene for neuronal nitric oxide synthase requires testosterone",
journal="Brain research",
year="1997",
author="Kriegsfeld, L. J. and Dawson, T. M. and Dawson, V. L. and Nelson, Randy J. and Snyder, S. H.",
volume="769",
number="1",
pages="66-70",
abstract="Nitric oxide acts as a neural messenger in both the central and peripheral nervous systems. Mice with targeted disruption of the neuronal isoform of nitric oxide synthase (nNOS - / -) are extremely aggressive relative to wild-type (WT) mice. Male nNOS - / - mice exhibit an increase in the number and duration of aggressive encounters compared to WT animals when tested in a variety of paradigms used to test rodent aggression. This inappropriate aggressive behavior has only been observed in male nNOS - /- mice; nNOS - /- females, like female WT mice, exhibit little or no aggression. The present study sought to test the dependence of increased aggressive behavior in nNOS - / - males on testosterone. Intact nNOS - / - males exhibited elevated levels of aggression relative to intact WT males. Castration reduced aggression in both WT and nNOS - /- males to equivalent low levels. Testosterone replacement restored aggression to precastration levels in both genotypes. These data provide evidence that increased aggressive behavior of nNOS - /- mice, like aggression in WT mice, is testosterone-dependent.<p /><p>Language: en</p>",
language="en",
issn="0006-8993",
doi="",
url="http://dx.doi.org/"
}