@article{ref1,
title="Prolonged treatment with beta-adrenoceptor antagonists counteracts the aggression deficit induced by chronic stress",
journal="Polish journal of pharmacology",
year="1997",
author="Zebrowska-Lupina, I. and Ossowska, G. and Lupina, T. and Klenk-Majewska, B.",
volume="49",
number="5",
pages="283-289",
abstract="Chronic stress-induced behavioral disturbances have been used as experimental models of depression. One of them is the deficit of fighting behavior induced by 16-day application of various unpredictable stressors. In the present study we investigated the effect of beta-adrenoceptor antagonists (propranolol, pindolol, nadolol and acebutolol) on electric footshock-induced fighting behavior in chronically stressed (14 various stressors over 16 days) male Wistar rats. It was found that the number of fighting attacks was reduced by about 50-80% in the rats submitted to chronic stress. Prolonged, 14-day, but not acute, treatment with propranolol, pindolol or nadolol (but not acebutolol) counteracted the deficit of aggression induced by chronic stress. It is suggested that beta-adrenoceptor antagonists which penetrate the blood-brain barrier may prevent the behavioral changes induced by chronic stress.<p /><p>Language: en</p>",
language="en",
issn="1230-6002",
doi="",
url="http://dx.doi.org/"
}