@article{ref1,
title="Relation of cerebral blood flow velocity and level of vigilance in humans",
journal="Neuroreport",
year="1997",
author="Schnittger, C. and Johannes, S. and Arnavaz, A. and Münte, T. F.",
volume="8",
number="7",
pages="1637-1639",
abstract="Blood flow velocities in both middle cerebral arteries (MCA) were measured using transcranial Doppler ultrasound (TCD) in healthy subjects engaged in a continuous static visual vigilance task. Stimuli comprised white vertical gratings on a black background with a size of 5 x 5&quot; (non-targets) or 5 x 3.5&quot; (targets). Button presses were required to the rare (8.5%) targets. Over the 30 min session a decrease in hit rate and an increase in reaction time were seen, indicating a decrease in vigilance. These performance changes were paralleled by a decrease in flow velocity in both MCAs. No hemispheric difference was seen. These data suggest a close coupling of performance and blood flow in vigilance tasks. Modulation of cholinergic activity during the vigilance task might be the common underlying mechanism.<p /><p>Language: en</p>",
language="en",
issn="0959-4965",
doi="",
url="http://dx.doi.org/"
}