@article{ref1,
title="Heat intolerance induced by antidepressants",
journal="Annals of the New York Academy of Sciences",
year="1997",
author="Epstein, Y. and Albukrek, D. and Kalmovitc, B. and Moran, D. S. and Shapiro, Y.",
volume="813",
number="",
pages="553-558",
abstract="A case in which prescription medications induced heat intolerance which led to heat stroke is presented. A subject who suffered from depression and was treated with fluoxetine HCL (prozac) and lithium carbonate was engaged in mild intermittent work for 4 hours under hot/dry climatic conditions (Ta = 37 degrees C, rh = 15%). The subject lost consciousness, was hyperthermic and suffered from disseminated intravascular coagulation. A year later residual cerebellar symptoms were still evident and severe atrophy of the cerebellar tissue was demonstrated in a CT scan. It is suggested that drug-induced heat intolerance was the predisposing factor that reduced the patient ability to sustain exercise-heat stress, and under the favorable environmental circumstances led to excessive heat accumulation which ultimately caused heat stroke. This is the first description, to our knowledge, of heat intolerance of a patient treated by a combination of fluoxetine and lithium carbonate.<p /><p>Language: en</p>",
language="en",
issn="0077-8923",
doi="",
url="http://dx.doi.org/"
}