@article{ref1,
title="Serotonergic function and self-injurious behavior in personality disorder patients",
journal="Psychiatry research",
year="1997",
author="New, A. S. and Trestman, R. L. and Mitropoulou, V. and Benishay, D. S. and Coccaro, E. and Silverman, Jay G. and Siever, Larry J.",
volume="69",
number="1",
pages="17-26",
abstract="Self-directed aggression, whether in the form of non-suicidal self-mutilation or suicidal behavior, is a prominent feature of personality disorders. We hypothesized that self-injurious behavior, like suicidal behavior, represents a form of self-directed aggression, and may, like suicidal behavior and impulsive aggression, be associated with a decrease in central serotonin function in personality disorder patients. Ninety-seven patients with DSM-III personality disorder underwent D,L-fenfluramine challenge as an assessment of serotonergic activity. Patients with a history of self-mutilation or suicide had blunted prolactin and cortisol responses to D,L-fenfluramine compared to those with neither, and those with both had the most blunted responses to fenfluramine. These data raise the possibility that the central 5-HT abnormality, previously associated with suicidal behavior, may be associated with self-directed violence and not necessarily specifically with suicidal intent.<p /><p>Language: en</p>",
language="en",
issn="0165-1781",
doi="",
url="http://dx.doi.org/"
}