@article{ref1,
title="Decreased striatal D1 binding as measured using PET and [11C]SCH 23,390 in patients with major depression with anger attacks",
journal="Depression and anxiety",
year="2006",
author="Dougherty, Darin D. and Bonab, Ali A. and Ottowitz, William E. and Livni, Eli and Alpert, Nathaniel M. and Rauch, Scott L. and Fava, Maurizio and Fischman, Alan J.",
volume="23",
number="3",
pages="175-177",
abstract="This study assessed striatal dopamine 1 (D1) receptor binding in patients with major depressive disorder and anger attacks (MDD+A) and healthy volunteers. We used positron emission tomography with [(11)C]SCH 23,390 to compare 10 patients with MDD+A to 10 healthy volunteers. [(11)C]SCH 23,390 binding in bilateral striata was significantly lower in the MDD+A group when compared to healthy volunteers. These results implicate striatal D1 receptor dysfunction in MDD+A and further suggest an association between dopaminergic transmission and anger or aggression.<p /><p>Language: en</p>",
language="en",
issn="1091-4269",
doi="10.1002/da.20168",
url="http://dx.doi.org/10.1002/da.20168"
}