@article{ref1,
title="Childhood neglect and abuse as predictors of antidepressant response in adult depression",
journal="Depression and anxiety",
year="2009",
author="Johnstone, Jeanette M. and Luty, Suzanne E. and Carter, Janet D. and Mulder, Roger T. and Frampton, Christopher M. A. and Joyce, Peter R.",
volume="26",
number="8",
pages="711-717",
abstract="BACKGROUND: Childhood neglect and abuse are recognized as risk factors for depression, but are not often studied as predictors of treatment response in depression. METHODS: Clinically depressed outpatients (n=195) were asked about childhood experiences before beginning a randomized antidepressant trial with either fluoxetine or nortriptyline. Three treatment outcomes were measured: Adequate trial, six-week response and two months sustained recovery. RESULTS: Patients reporting low paternal care (paternal neglect), as measured by the Parental Bonding Instrument (PBI), were less likely to complete an adequate six-week trial of medication. Patients who reported high maternal protection (maternal overprotection) on the PBI had poorer treatment response in the short-term at six weeks, and longer term, for two months of sustained recovery. However, abuse, whether sexual, physical, or psychological in nature, did not predict treatment response. CONCLUSIONS: The experience of having a neglectful father or an overprotective mother was more predictive of response to treatment for depression than abuse, suggesting that the quality of ongoing intra-familial relationships has a greater impact on treatment outcomes for depression than experiences of discrete abuse in childhood.<p /><p>Language: en</p>",
language="en",
issn="1091-4269",
doi="10.1002/da.20590",
url="http://dx.doi.org/10.1002/da.20590"
}