@article{ref1,
title="A family history study of intermittent explosive disorder",
journal="Journal of psychiatric research",
year="2010",
author="Coccaro, Emil F.",
volume="44",
number="15",
pages="1101-1105",
abstract="BACKGROUND: Intermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression. Since aggression and impulsivity are under genetic influence, IED may be familial. METHODS: Blinded and controlled family history study of IED and co-morbid conditions in an outpatient clinical research center for impulsive aggression. The subjects were first-degree relatives of individuals who did and did not meet criteria for IED by DSM-IV and Research Criteria. RESULTS: Elevated Morbid Risk of IED was observed in relatives of IED Probands compared with relatives of Non-IED Probands. This familial signal of IED was not affected by comorbidity in the IED Probands of comorbidity in the relatives of the IED Probands. CONCLUSIONS: IED, as defined by research criteria, appears to be familial and may not be an artifact of other co-morbid conditions.<p /> <p>Language: en</p>",
language="en",
issn="0022-3956",
doi="10.1016/j.jpsychires.2010.04.006",
url="http://dx.doi.org/10.1016/j.jpsychires.2010.04.006"
}