@article{ref1,
title="Enhanced aggressive behavior in mice lacking 5-HT1B receptor",
journal="Science",
year="1994",
author="Saudou, F. and Amara, D. A. and Dierich, A. and LeMeur, M. and Ramboz, S. and Segu, L. and Buhot, M. C. and Hen, R.",
volume="265",
number="5180",
pages="1875-1878",
abstract="The neuromodulator serotonin (5-hydroxytryptamine, 5-HT) has been associated with mood disorders such as depression, anxiety, and impulsive violence. To define the contribution of 5-HT receptor subtypes to behavior, mutant mice lacking the 5-HT1B receptor were generated by homologous recombination. These mice did not exhibit any obvious developmental or behavioral defects. However, the hyperlocomotor effect of the 5-HT1A/1B agonist RU24969 was absent in mutant mice, indicating that this effect is mediated by 5-HT1B receptors. Moreover, when confronted with an intruder, mutant mice attacked the intruder faster and more intensely than did wild-type mice, suggesting the participation of 5-HT1B receptors in aggressive behavior.<p /><p>Language: en</p>",
language="en",
issn="0036-8075",
doi="",
url="http://dx.doi.org/"
}