@article{ref1,
title="Development and expression of hormonal systems regulating aggression",
journal="Annals of the New York Academy of Sciences",
year="1996",
author="Simon, N. G. and McKenna, S. E. and Lu, S. F. and Cologer-Clifford, A.",
volume="794",
number="",
pages="8-17",
abstract="There are multiple pathways involved in the regulation of male typical aggression by T, and the functional pathway is determined by genotype. Target-tissue sensitivity to the aggression-promoting properties of T and its estrogenic and androgenic metabolites is determined by a complex sequence of events in which steroid receptors play a critical role. To date, it appears that the relative density of AR may be an important factor in the biobehavioral effects of androgens. Regarding sensitivity to estrogens, characterization of ER-NM interactions, and understanding of the contribution of the two activating functions within ER, appears to be necessary to comprehensively describe the cellular basis for responsiveness to the aggression-promoting effect of this T metabolite. In broader terms, these observations indicate that understanding the relationship between T and the expression of aggression in humans will require models that incorporate cellular aspects of steroid hormone action, including metabolism, receptor function, and gene regulation.<p /><p>Language: en</p>",
language="en",
issn="0077-8923",
doi="",
url="http://dx.doi.org/"
}