@article{ref1,
title="Use of fluoxetine to treat dominance aggression in dogs",
journal="Journal of the American Veterinary Medical Association",
year="1996",
author="Dodman, N. H. and Donnelly, R. and Shuster, L. and Mertens, P. and Rand, W. and Miczek, Klaus A.",
volume="209",
number="9",
pages="1585-1587",
abstract="OBJECTIVE: To evaluate fluoxetine for the treatment of owner-directed dominance aggression in dogs. DESIGN: Prospective study. ANIMALS: 9 dogs of various breeds, ages, and either sex determined to have owner-directed dominance aggression. PROCEDURE: Placebo and fluoxetine (1 mg/kg of body weight) were compared for the treatment of owner-directed dominance aggression in a single-blind crossover study. Owners were instructed to record aggressive and nonaggressive responses of their dogs daily on a canine-overt aggression chart for the 5-week duration of the study. Total aggression scores (linear and geometric) were calculated for each week of the study. The frequency of individual responses was also analyzed independently. RESULTS: Fluoxetine resulted in a significant (P = 0.01) reduction in owner-directed dominance aggression after 3 weeks of treatment. No particular aggressive response accounted for the overall reduction in aggression. CLINICAL IMPLICATIONS: Fluoxetine may be useful in the management of dominance aggression in dogs.<p /><p>Language: en</p>",
language="en",
issn="0003-1488",
doi="",
url="http://dx.doi.org/"
}