@article{ref1,
title="Suppressing aggressive behavior with analogs of allopregnanolone (epalon)",
journal="Steroids",
year="2001",
author="Slavíková, B. and Kasal, A. and Uhlírová, L. and Krsiak, M. and Chodounská, H. and Kohout, L.",
volume="66",
number="2",
pages="99-105",
abstract="3alpha-Hydroxy-20-oxo-5alpha-pregnan-21-yl hemisuccinate (8) was produced by partial acylation of 3alpha,21-dihydroxy-5alpha-pregnan-20-one (14). 3alpha-Fluoro-5alpha-pregnan-20-one (9) was prepared by treatment of 3beta-hydroxy-5alpha-pregnan-20-one (11) with DAST and by solvolysis of tosylate 12 with tetrabutylammonium fluoride. A behavioral test on mice was performed using 3alpha-hydroxy-5alpha-pregnan-20-one (1) and compounds 8 and 9. Compound 8 was found to be inactive, while the fluoro derivative 9 selectively reduced aggressive behavior in mice more than the corresponding 3alpha-hydroxy compound 1; locomotion and other behavioral features were not affected.<p /><p>Language: en</p>",
language="en",
issn="0039-128X",
doi="",
url="http://dx.doi.org/"
}