@article{ref1,
title="Suicide, impulsive aggression, and HTR1B genotype",
journal="Biological psychiatry",
year="2001",
author="New, A. S. and Gelernter, J. and Goodman, M. and Mitropoulou, V. and Koenigsberg, H. and Silverman, Jay G. and Siever, Larry J.",
volume="50",
number="1",
pages="62-65",
abstract="BACKGROUND: Suicidality and impulsive aggression are partially heritable, and postmortem brain studies suggest that abnormalities in serotonin 1B may be associated with suicide. Studies of serotonin 1B &quot;knockout&quot; mice show an increase in aggressive behavior relative to wild-type mice. METHODS: We assessed the relationship between genotype at the HTR1B locus and both suicide history and impulsive aggression in personality disorders. RESULTS: The &quot;G&quot; allele of a polymorphic gene at the HTR1B locus was associated with a history of suicide attempts in white patients with personality disorders [chi(2)(1) = 9.3, p =.01, n = 90]. No relationship was found between HTR1B genotype and self-reported impulsive aggression. CONCLUSIONS: This preliminary finding suggests that allelic variability at the HTR1B locus may be associated with the susceptibility to suicide attempts in patients with personality disorders.<p /><p>Language: en</p>",
language="en",
issn="0006-3223",
doi="",
url="http://dx.doi.org/"
}