@article{ref1,
title="Molecular basis of aggression",
journal="Trends in neurosciences",
year="2001",
author="Nelson, Randy J. and Chiavegatto, S.",
volume="24",
number="12",
pages="713-719",
abstract="Recent pharmacological and genetic studies have dramatically expanded the list of neurotransmitters, hormones, cytokines, enzymes, growth factors, and signaling molecules that influence aggression. In spite of this expansion, serotonin (5-HT) remains the primary molecular determinant of inter-male aggression, whereas other molecules appear to act indirectly through 5-HT signaling. We review evidence of interactions among these molecules and aggressive behavior. Slight modulations in 5-HT levels, turnover, and metabolism, or in receptor subtype activation, density, and binding affinity affect aggression. Activation of specific 5-HT receptors evokes distinct, but highly interacting, second messenger systems and multiple effectors. Understanding the interactions between 5-HT receptor subtypes should lead to novel insights into the molecular mechanisms of aggression.<p /><p>Language: en</p>",
language="en",
issn="0166-2236",
doi="",
url="http://dx.doi.org/"
}