@article{ref1,
title="Corticosterone increases depression-like behavior, with some effects on predator odor-induced defensive behavior, in male and female rats",
journal="Behavioral neuroscience",
year="2004",
author="Kalynchuk, Lisa E. and Gregus, Andrea and Boudreau, Daniel and Perrot-Sinal, Tara S.",
volume="118",
number="6",
pages="1365-1377",
abstract="This experiment examined the effect of repeated corticosterone injections on anxiety and depression-like behavior in male and female rats. Rats received either corticosterone or vehicle injections for 21 consecutive days prior to behavioral testing in the forced swim, open-field, and predator odor tests. The corticosterone injections significantly increased depression-like behavior in the forced swim test in both male and female rats but had no significant effect on anxiety in the open-field test. In the predator odor test, the corticosterone injections significantly increased a subset of defensive behaviors in the male rats. These results suggest that repeated exposure to corticosterone increases depression-like behavior, with some effects on anxiety, and that male rats may be more affected than female rats by this manipulation.<p /><p>Language: en</p>",
language="en",
issn="0735-7044",
doi="10.1037/0735-7044.118.6.1365",
url="http://dx.doi.org/10.1037/0735-7044.118.6.1365"
}