@article{ref1,
title="Serotonergic functioning in children with oppositional defiant disorder: a sumatriptan challenge study",
journal="Biological psychiatry",
year="2002",
author="Snoek, Heddeke and Van Goozen, Stephanie H. M. and Matthys, Walter and Sigling, Hein O. and Koppeschaar, Hans P. F. and Westenberg, Herman G. M. and Van Engeland, Herman",
volume="51",
number="4",
pages="319-325",
abstract="BACKGROUND: Several studies support the notion that disturbances in the central serotonergic function are related to impulsive aggression. There is recent evidence from studies on 5-HT(1B) knock-out mice that this specific receptor is involved in impulsive aggressive behavior. The aim of the present study was to investigate 5-HT(1B/1D) receptor functioning in normal intelligent hospitalized children with oppositional defiant disorder (ODD). METHODS: The growth hormone (GH) response to a challenge with the 5-HT(1B/1D) agonist sumatriptan was examined in 20 children with an ODD, of whom 13 had an attention-deficit/hyperactivity disorder comorbidity, and 15 normal control subjects (NC). Blood samples for growth hormone were collected repeatedly between 8:30 and 12:00 AM. Sumatriptan was administered at 10 AM. The effect of stress due to this procedure was assessed by measuring salivary cortisol. RESULTS: The GH response was significantly stronger in the children with ODD. After sumatriptan injection NC children showed a significant increase in cortisol; no such pattern was present in the ODD group. CONCLUSIONS: The results suggest that the postsynaptic 5-HT(1B/1D) receptor is functionally more sensitive in children with ODD.<p /><p>Language: en</p>",
language="en",
issn="0006-3223",
doi="",
url="http://dx.doi.org/"
}