@article{ref1,
title="Serotonergic function in children with attention-deficit hyperactivity disorder: relationship to later antisocial personality disorder",
journal="British journal of psychiatry",
year="2007",
author="Flory, Janine D. and Newcorn, Jeffrey H. and Miller, Carlin and Harty, Seth and Halperin, Jeffrey M.",
volume="190",
number="",
pages="410-414",
abstract="BACKGROUND: Impulsive aggression in adulthood is associated with disturbances in serotonergic function. In contrast, research examining this association in childhood has yielded inconsistent results. AIMS: The current study examined the prospective relationship between serotonergic function measured in childhood and the later emergence of antisocial personality disorder. METHOD: Hormonal response to fenfluramine, an index of serotonergic function, was assessed in 58 children with attention-deficit hyperactivity disorder between 1990 and 1997 when they were aged 7-11 years. Approximately 9 years later these individuals were evaluated for antisocial personality disorder. RESULTS: Lower serotonergic responsivity assessed in childhood predicted the development of antisocial personality disorder (t (56)=2.25, P=0.028). CONCLUSIONS: These results provide a critical link between the child and adult literature on the covariation of impulsive aggression and serotonergic function and suggest a potential explanation for inconsistencies in the childhood literature.<p /><p>Language: en</p>",
language="en",
issn="0007-1250",
doi="10.1192/bjp.bp.106.027847",
url="http://dx.doi.org/10.1192/bjp.bp.106.027847"
}