@article{ref1,
title="Aggressive behavior and neuroleptic medication are associated with increased number of alpha1-adrenoceptors in patients with Alzheimer disease",
journal="American journal of geriatric psychiatry",
year="2007",
author="Sharp, Sally I. and Ballard, Clive G. and Chen, Christopher P. L-H and Francis, Paul T.",
volume="15",
number="5",
pages="435-437",
abstract="OBJECTIVE: Aggressive behavior in dementia is a major clinical management problem. METHOD: Postmortem brain tissue was obtained from 24 patients with Alzheimer disease (AD) and 25 comparison cases. [3H] Prazosin binding to alpha1-AdR was determined. RESULTS: Aggressive behavior was significantly correlated with alpha1-adrenoceptor number in patients with AD (R(s)=0.454, N=24). Furthermore, patients receiving ongoing neuroleptics had significantly higher Bmax for [3H] prazosin (21 +/- 2, N=9) than those who were not (16 +/- 1, N=15). CONCLUSIONS: Upregulation of alpha1-AdR is associated with aggressive behavior and chronic treatment with neuroleptic medication.<p /><p>Language: en</p>",
language="en",
issn="1064-7481",
doi="10.1097/01.JGP.0000237065.78966.1b",
url="http://dx.doi.org/10.1097/01.JGP.0000237065.78966.1b"
}