@article{ref1,
title="Lamotrigine treatment of aggression in female borderline patients, Part II: an 18-month follow-up",
journal="Journal of psychopharmacology",
year="2008",
author="Leiberich, P. and Nickel, M. K. and Tritt, K. and Pedrosa Gil, F.",
volume="22",
number="7",
pages="805-808",
abstract="Borderline patients often display pathological aggression. We previously tested lamotrigine, an anti-convulsant, in therapy for aggression in women with borderline personality disorder (BPD) (J Psychopharmacol 2005; 19: 287-291), and found significant changes on most scales of the State-Trait Anger Expression Inventory (STAXI) after eight weeks. To assess the longer-term efficacy of lamotrigine in therapy for aggression in women with BPD, this 18-month follow-up observation was carried out, in which patients (treated with lamotrigine: n = 18; former placebo group: n = 9) were tested every six months. According to the intent-to-treat principle, significant changes on all scales of the STAXI were observed in the lamotrigine-treated subjects. All subjects tolerated lamotrigine relatively well. Lamotrigine appears to be an effective and relatively safe agent in the longer-term treatment of aggression in women with BPD.<p /><p>Language: en</p>",
language="en",
issn="0269-8811",
doi="10.1177/0269881107084004",
url="http://dx.doi.org/10.1177/0269881107084004"
}