@article{ref1,
title="Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene",
journal="Science",
year="2003",
author="Caspi, Avshalom and Sugden, Karen and Moffitt, Terrie E. and Taylor, Alan and Craig, Ian W. and Harrington, HonaLee and McClay, Joseph and Mill, Jonathan and Martin, Judy and Braithwaite, Antony and Poulton, Richie",
volume="301",
number="5631",
pages="386-389",
abstract="In a prospective-longitudinal study of a representative birth cohort, we tested why stressful experiences lead to depression in some people but not in others. A functional polymorphism in the promoter region of the serotonin transporter (5-HT T) gene was found to moderate the influence of stressful life events on depression. Individuals with one or two copies of the short allele of the 5-HT T promoter polymorphism exhibited more depressive symptoms, diagnosable depression, and suicidality in relation to stressful life events than individuals homozygous for the long allele. This epidemiological study thus provides evidence of a gene-by-environment interaction, in which an individual's response to environmental insults is moderated by his or her genetic makeup.<p /><p>Language: en</p>",
language="en",
issn="0036-8075",
doi="10.1126/science.1083968",
url="http://dx.doi.org/10.1126/science.1083968"
}