@article{ref1,
title="Pharmacological activity of the new adamantane derivative--potential antiparkinson preparation during subchronic administration",
journal="Eksperimental'naia i Klinicheskaia Farmakologiia",
year="2000",
author="Val'dman, E. A.",
volume="63",
number="5",
pages="3-6",
abstract="The effect of a new potential antiparkinsonian drug, N-(2-adamantyl)hexamethyleneimine hydrochloride (A-7), upon some behavioral parameters was studied in rats after subchronic 14-day treatment. Also studied was the effect of abrupt termination of a prolonged (22-day) drug administration. The subchronic treatment with A-7 at a dose of 10, 20, or 40 mg/kg did not produce significant changes in coordination, explorative behavior, muscle tone, and aggression level. At the same time, the 14-day treatment with A-7 at a dose of 10 mg/kg increased the pain threshold; A-7 at a dose of 40 mg/kg (but not 10 or 20 mg/kg) increased the spontaneous motor activity. Upon abrupt termination of the drug administration after a prolonged treatment sensitivity of the test animals with respect to the MFTP neurotoxin as compared to that observed in the non-drug control group.<p /><p>Language: ru</p>",
language="ru",
issn="0869-2092",
doi="",
url="http://dx.doi.org/"
}