@article{ref1,
title="Involvement of GABAergic neurotransmission in the neurobiology of the apomorphine-induced aggressive behavior paradigm, a model of psychotic behavior in rats",
journal="Methods and findings in experimental and clinical pharmacology",
year="2000",
author="Rudissaar, R. and Pruus, K. and Skrebuhhova-Malmros, T. and Allikmets, L. and Matto, V.",
volume="22",
number="8",
pages="637-640",
abstract="The effect of treatment with the acute GABAA receptor agonist THIP and the GABAB receptor agonist baclofen on apomorphine-induced aggressive behavior was studied in adult male Wistar rats. Both THIP (10 mg/kg i.p.) and baclofen (8 mg/kg i.p.) attenuated the aggressiveness, thereby indicating the involvement of GABAergic neurotransmission in the mediation of apomorphine-induced aggressiveness. On the basis of our data it can be proposed that both GABAA and GABAB receptor subtypes are involved in the neurobiology of apomorphine-induced aggressive behavior, as this phenomenon is evidently subject to the general inhibitory effect of GABAergic neurotransmission.<p /><p>Language: en</p>",
language="en",
issn="0379-0355",
doi="",
url="http://dx.doi.org/"
}