@article{ref1,
title="N-Acetylaspartate concentration in the anterior cingulate of maltreated children and adolescents with PTSD",
journal="American journal of psychiatry",
year="2000",
author="De Bellis, M. D. and Keshavan, M. S. and Spencer, S. and Hall, J.",
volume="157",
number="7",
pages="1175-1177",
abstract="OBJECTIVE: Anterior cingulate dysfunction has been implicated in the pathophysiology of posttraumatic stress disorder (PTSD). The authors hypothesized that integrity of the anterior cingulate may be affected in childhood PTSD. METHOD: Single voxel proton magnetic resonance spectroscopy (proton MRS) was used to measure the relative concentration of N-acetylaspartate and creatine, a marker of neural integrity, in the anterior cingulate of 11 children and adolescents who met DSM-IV criteria for PTSD secondary to maltreatment and 11 healthy matched comparison subjects. RESULTS: The ratio of N-acetylaspartate to creatine was significantly lower in the maltreated subjects with PTSD than in the comparison subjects. CONCLUSIONS: The lower N-acetylaspartate/creatine ratio in subjects with PTSD suggests that anterior cingulate neuronal metabolism may be altered in childhood PTSD.<p /><p>Language: en</p>",
language="en",
issn="0002-953X",
doi="",
url="http://dx.doi.org/"
}