@article{ref1,
title="Naloxone-induced opiate withdrawal produces long-lasting and context-independent changes in aggressive and social behaviors of postdependent male mice",
journal="Behavioral neuroscience",
year="2000",
author="Felip, C. M. and Rodríguez-Arias, M. and Espejo, E. F. and Miñarro, J. and Stinus, L.",
volume="114",
number="2",
pages="424-430",
abstract="The purpose of this study was to determine whether an environment associated with naloxone-induced morphine withdrawal affects aggressive or social behaviors in postdependent mice. Morphine-dependent or saline-treated mice received 3 naloxone injections in 1 of 2 different environments (A or B); 15 days afterward, when the mice were completely drug free, an aggression test was carried out in Environment A. All the mice suffering morphine withdrawal showed a significant increase in aggression, irrespective of the environment in which the withdrawal took place. In these conditions, the impact of morphine dependence and the 3 induced withdrawals was so profound that the environment could not be discriminative. In addition, modifications in the behavioral profile of postdependent mice that suffered only spontaneous withdrawal were long-lasting, with the mice carrying out more attacks during social investigation without presenting threat postures.<p /><p>Language: en</p>",
language="en",
issn="0735-7044",
doi="",
url="http://dx.doi.org/"
}