@article{ref1,
title="Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders",
journal="Biological psychiatry",
year="2000",
author="Bellivier, F. and Szöke, A. and Henry, C. and Lacoste, J. and Bottos, C. and Nosten-Bertrand, M. and Hardy, P. and Rouillon, Frédéric and Launay, J. M. and Laplanche, J. L. and Leboyer, M.",
volume="48",
number="4",
pages="319-322",
abstract="BACKGROUND: Genes involved in the serotonin system are major candidates in association studies of suicidal behavior. In this case-control study we investigated whether the serotonin transporter (5-HTT) gene encoding the protein responsible for the reuptake of serotonin from the synapse after its release from serotonergic neurons is a susceptibility factor for suicidal behavior. METHODS: A functional polymorphism of the 5-HTT gene (a 44-base pair insertion/deletion in the 5-HTT-linked polymorphic region [5-HTTLPR]) was studied in a population of 237 consecutive patients with affective disorder (unipolar or bipolar) and 187 control subjects. Ninety-nine patients had attempted suicide at least once, of whom 26 made a violent attempt. RESULTS: No association was found between the &quot;s&quot; allele of the 5-HTTLPR and suicide attempt; however, there was a significant difference in allele distributions between patients who had made violent suicide attempts and control subjects. CONCLUSIONS: A genetic variant of the 5-HTT gene may predispose individuals to violent suicidal behavior. The precise phenotype associated with the 5-HTT gene is unclear, and therefore further studies are required to replicate these findings.<p /><p>Language: en</p>",
language="en",
issn="0006-3223",
doi="",
url="http://dx.doi.org/"
}