@article{ref1,
title="Synthesis and properties of the derivatives of 2-alkylthio-4-oxo-3,4- (and -1,4)-dihydropyrido-[2,3-d]pyrimidine-5- and -6-carboxylic acids",
journal="Farmaco (Società chimica italiana : 1989)",
year="1990",
author="Sladowska, H. and Bartoszko-Malik, A. and Zawisza, T.",
volume="45",
number="1",
pages="111-121",
abstract="Condensation of diethyl 2-amino-6-methylpyridine-3,4-dicarboxylate (I) with the corresponding isothiocyanates afforded derivatives of ethyl 4-oxo-2-thioxo-1,2,3,4-tetrahydropyrido [2,3-d]pyrimidine-5-carboxylate (V-VII). Alkylation of (V), (VI) and (XI) gave the corresponding derivatives of ethyl 2-alkylthio-4-oxo-3,4-(and 1,4)-dihydropyrido[2,3-d]pyrimidine-5- and -6- carboxylate [(XII-XVI), (XX-XXII)]. Some of the obtained compounds were active pharmacologically.<p /><p>Language: en</p>",
language="en",
issn="0014-827X",
doi="",
url="http://dx.doi.org/"
}