@article{ref1,
title="Serotonergic responses in depressed patients with or without a history of alcohol use disorders and healthy controls",
journal="European Neuropsychopharmacology",
year="2008",
author="Sher, Leo and Stanley, Barbara H. and Cooper, Thomas B. and Malone, Kevin M. and Mann, J. John and Oquendo, Maria A.",
volume="18",
number="9",
pages="692-699",
abstract="Dysfunction of serotonergic neurotransmission has been implicated in the etiopathogenesis of major depression (MDD) and alcohol use disorders (AUD). To compare serotonin function in MDD with co-occurring AUD (MDD/AUD), MDD without co-occurring AUD (MDD only) and healthy controls (HC) we sought to study differences in prolactin responses to fenfluramine administration in patients with MDD/AUD, patients with MDD only and HC. In all, 169 subjects (62 MDD/AUD, 75 MDD only, and 32 HC) were entered into the study. Controlling for gender, prolactin responses were lower in the MDD/AUD group compared to the MDD only or the HC group. Controlling for gender and aggression, prolactin responses in the MDD/AUD group remained significantly lower compared to the HC group but the difference between the MDD/AUD and the MDD only groups disappeared. The difference in prolactin responses between MDD/AUD and MDD only could be attributed to higher aggression scores in the MDD/AUD group compared to the MDD group.<p /><p>Language: en</p>",
language="en",
issn="0924-977X",
doi="10.1016/j.euroneuro.2008.05.005",
url="http://dx.doi.org/10.1016/j.euroneuro.2008.05.005"
}