@article{ref1,
title="Catechol-O-methyltransferase Val158Met polymorphism in relation to aggressive schizophrenia in a Korean population",
journal="European Neuropsychopharmacology",
year="2008",
author="Kim, Youl-Ri and Kim, Jeong Hyun and Kim, Se Joo and Lee, Dongeun and Min, Sung Kil",
volume="18",
number="11",
pages="820-825",
abstract="We examined the association between the Catechol-O-methyltransferase (COMT) Val158Met polymorphism and aggressive schizophrenia. The sample included 61 aggressive schizophrenic patients as well as 104 non-aggressive patients from psychiatric hospitals and 415 healthy volunteers in South Korea. In the case-control comparisons, there was no significant association between the aggressive schizophrenic patients and the COMT Val158Met polymorphism. Looking only at the subgroup of aggressive schizophrenic patients, however, we found a dose-dependent relationship between the Met allele and verbal aggression. In this subgroup, the Met carriers showed a higher verbal aggression score than those with the Val/Val homozygote. These findings support the hypothesized moderating role of the COMT gene in the aggressive behaviour in some schizophrenic patients, though they do not support the existence of a direct association between the COMT Val158Met polymorphism and aggressive schizophrenia case status in the Korean population.<p /><p>Language: en</p>",
language="en",
issn="0924-977X",
doi="10.1016/j.euroneuro.2008.07.009",
url="http://dx.doi.org/10.1016/j.euroneuro.2008.07.009"
}