@article{ref1,
title="Trial design challenges when combining medication and parent training in children with pervasive developmental disorders",
journal="Journal of autism and developmental disorders",
year="2009",
author="Scahill, Lawrence and Aman, Michael G. and McDougle, Christopher J. and Arnold, L. Eugene and McCracken, James T. and Handen, Benjamin and Johnson, Cynthia and Dziura, James D. and Butter, Eric and Sukhodolsky, Denis and Swiezy, Naomi and Mulick, James and Stigler, Kimberly and Bearss, Karen and Ritz, Louise and Wagner, Ann and Vitiello, Benedetto",
volume="39",
number="5",
pages="720-729",
abstract="This paper presents the rationale for a 24-week, randomized trial designed to test whether risperidone plus structured parent training would be superior to risperidone only on measures of noncompliance, irritability and adaptive functioning. In this model, medication reduces tantrums, aggression and self-injury; parent training promotes improvement in noncompliance and adaptive functioning. Thus, medication and parent training target related, but separate, outcomes. At week 24, the medication was gradually withdrawn to determine whether subjects in the combined treatment group could be managed on a lower dose or off medication without relapse. Both symptom reduction and functional improvement are important clinical treatment targets. Thus, experimental evidence on the beneficial effects of combining pharmacotherapy and exportable behavioral interventions is needed to guide clinical practice.<p /><p>Language: en</p>",
language="en",
issn="0162-3257",
doi="10.1007/s10803-008-0675-2",
url="http://dx.doi.org/10.1007/s10803-008-0675-2"
}