@article{ref1,
title="The predictive value of benzodiazepine tolerance in persistently aggressive schizophrenia",
journal="Neuropsychobiology",
year="1999",
author="Hatta, K. and Takahashi, Toru and Nakamura, Hideki and Yamashiro, H. and Endo, H. and Kito, K. and Fujii, S. and Matsuzaki, I. and Masui, K. and Yonezawa, Y.",
volume="39",
number="4",
pages="196-199",
abstract="The aim of this study was to determine whether benzodiazepine tolerance might provide a predictive marker for persistent aggression in schizophrenia. Seventy-seven male schizophrenic patients newly admitted to our psychiatric intensive care unit due to violent behavior during a 4-month period were examined. As a result, a high dose of benzodiazepine required for sedation or a short duration until regaining consciousness after the initial sedation, was related to severer aggression on waking up after sedation. Despite the small number of subjects examined, a conservative claim can be made that the level of the effect of benzodiazepine required for sedation seems to predict persistent severe aggression in schizophrenia.<p /><p>Language: en</p>",
language="en",
issn="0302-282X",
doi="",
url="http://dx.doi.org/"
}