@article{ref1,
title="Estrogen therapy and aggressive behavior in elderly patients with moderate-to-severe dementia: results from a short-term, randomized, double-blind trial",
journal="American journal of geriatric psychiatry",
year="1999",
author="Kyomen, H. H. and Satlin, A. and Hennen, J. and Wei, J. Y.",
volume="7",
number="4",
pages="339-348",
abstract="The authors used a randomized, double-blind, placebo-controlled clinical trial study design to investigate the efficacy and safety of short-term estrogen therapy in decreasing aggressive behaviors in elderly patients with moderate-to-severe dementia. Estrogen therapy was associated with lower total aggression scores (P<0.030) and with decreased frequency of physical aggression (P<0.019) over the 4-week trial. Verbally aggressive behaviors were decreased relative to control subjects, although this effect was not statistically significant. No drug-vs.-placebo differences were found for resistive, sexual, or self-directed aggressive behaviors. No adverse effects from the estrogen were observed during the course of the study.<p /><p>Language: en</p>",
language="en",
issn="1064-7481",
doi="",
url="http://dx.doi.org/"
}