@article{ref1,
title="Neuroanatomy of childhood disruptive behavior disorders",
journal="Aggressive behavior",
year="2011",
author="Perusse, Daniel and Evans, Alan and Chen, John and Yoon, Uicheul and He, Yong and Fahim, Cherine",
volume="37",
number="4",
pages="326-337",
abstract="Our aims were to (1) examine possible neuroanatomical abnormalities associated with the Disruptive Behavior Disorders (DBDs) as a group and (2) assess neuroanatomical anomalies specific to each DBD (i.e., conduct disorder [CD] and oppositional defiant disorder). Cortical thickness analysis and voxel-based morphometry were analyzed in 47 8-year-old boys (22 DBDs with and without CD and/or ODD and 25 healthy controls) from Magnetic Resonance Imaging brain scans. DBD symptoms were assessed using the Dominic-R. In DBD subjects relative to controls, we found (1) a decreased overall mean cortical thickness; (2) thinning of the cingulate, prefrontal and insular cortices; and (3) decreased gray matter density (GMd) in the same brain regions. We also found that scores on the Dominic-R were negatively correlated with GMd in the prefrontal and precuneus/superior temporal regions. There was a subdiagnostic main effect for CD, related to thinning of the middle/medial frontal, and for ODD in the left rectal/orbitofrontal. Findings suggest that thinning and decreased GMd of the insula disorganizes prefrontal circuits, diminishing the inhibitory influence of the prefrontal cortex on anger, aggression, cruelty, and impulsivity, and increasing a person's likelihood of aggressive behavior. These findings have implications for pathophysiologic models of the DBDs, their diagnostic classification system, and for designing more effective intervention programs. Aggr. Behav. 37:1-12, 2011. © 2011 Wiley-Liss, Inc.<p /> <p>Language: en</p>",
language="en",
issn="0096-140X",
doi="10.1002/ab.20396",
url="http://dx.doi.org/10.1002/ab.20396"
}