@article{ref1,
title="Does early improvement in major depression protect against treatment emergent suicidal ideation?",
journal="Journal of affective disorders",
year="2010",
author="Seemüller, Florian and Schennach-Wolff, Rebecca and Obermeier, Michael and Henkel, Verena and Möller, Hans Jürgen and Riedel, Michael",
volume="124",
number="1-2",
pages="183-186",
abstract="OBJECTIVE: To investigate the association of early improvement and treatment emergent suicidal ideation in a large sample (N=705) of naturalistically treated inpatients with major depressive disorder. METHOD: In line with previous reports early improvement was defined as a 20% HAMD improvement within the first two weeks of antidepressant treatment. Treatment emergent suicidal ideation was defined by a sudden increase from 0 or 1 to at least 3 on HAMD item 3 and from 0.1 to at least 4 on MADR item 10 for suicidal ideation. Early improvers were compared with non-early improvers with respect to the occurrence of treatment emergent suicidality during treatment. RESULTS: Early improvers were 3 (MADRS) to 3.4 (HAMD) times less likely to experience new emergence of suicidal ideation during the treatment course than non-improvers. In addition, early improvement was associated with significantly less pessimistic thoughts. LIMITATIONS: The analysis is based on secondary analysis of prospectively collected data. No controlled study design. CONCLUSION: Early improvement is associated with significantly less treatment emergent suicidal ideation for it may provide rapid symptom relief and reduce hopelessness.<p /> <p>Language: en</p>",
language="en",
issn="0165-0327",
doi="10.1016/j.jad.2009.10.010",
url="http://dx.doi.org/10.1016/j.jad.2009.10.010"
}