@article{ref1,
title="Relationship between retinal nerve fiber layer thickness and driving ability in patients with human immunodeficiency virus infection",
journal="Graefe's archive for clinical and experimental ophthalmology",
year="2011",
author="Cheng, Sarah and Klein, Helaina and Bartsch, Dirk-Uwe and Kozak, Igor and Marcotte, Thomas D. and Freeman, William R.",
volume="249",
number="11",
pages="1643-1647",
abstract="BACKGROUND: The aim of this work is to study the possible association between retinal nerve fiber layer (NFL) thickness and driving ability. METHODS: Thirty-eight drivers including 22 HIV-positive (HIV+) and 16 age-matched HIV-negative controls participants underwent a full ophthalmologic evaluation, including assessment of retinal NFL thickness. In the undilated state with standard optical correction and under standard illumination they also completed a computer-based, wide field-of-view driving simulation in which they were to obey traffic laws, engage in crash avoidance, and pass slower automobiles. Crashes, speeding and traffic light tickets, and off-road excursions contributed to a weighted score of driving errors. RESULTS: HIV-seropositive participants had a significantly higher weighted error score than control participants (18.4 [9.2] vs. 11.1 [4.5], p = 0.006). NFL thickness was significantly correlated with driving errors (r = -0.51, p = 0.025); there was a trend for participants with a CD4 nadir <100 to have more errors than those with a nadir >100 (29.7 [13.2] vs. 19.3 [8.4], p = 0.056). The highest number of driving errors occurred in individuals with both CD4 <100 and NFL thickness <80. CONCLUSIONS: Driving ability may be impacted by reductions in retinal nerve fiber layer thickness. Physicians should consider the potential impact that more complex ophthalmologic conditions in HIV-infected patients may have on driving performance.<p /> <p>Language: en</p>",
language="en",
issn="0721-832X",
doi="10.1007/s00417-011-1735-4",
url="http://dx.doi.org/10.1007/s00417-011-1735-4"
}