@article{ref1,
title="ECG changes and plasma concentrations of propafenone and its metabolites in a case of severe poisoning",
journal="Journal of toxicology - clinical toxicology",
year="1998",
author="Fonck, K. and Haenebalcke, C. and Hemeryck, A. and Belpaire, F. and Jordaens, L. and Calle, Paul and Buylaert, W.",
volume="36",
number="3",
pages="247-251",
abstract="Case report: Propafenone is a class IC antiarrhythmic agent metabolized into two major metabolites, 5-hydroxypropafenone and N-depropylpropafenone. The potency of 5-hydroxypropafenone to block fast sodium channels is comparable to that of its parent. We report the positive correlation between plasma concentrations and electrocardiographic changes in a patient with severe oral self-poisoning. Serial ECG changes were measured and plasma concentrations were determined by high-performance liquid chromatography. The initial plasma concentrations of propafenone were in the toxic range and correlated with the widening of the QRS-complex. The slow decline in concentration during this first phase might relate to saturation of the isoenzyme CYP2D6. The half-life of propafenone, calculated from the second phase, was approximately 3 hours, defining the patient as a fast metabolizer. The initial concentrations of the metabolite N-depropylpropafenone were surprisingly higher than those of 5-hydroxypropafenone which may also be due to saturation of CYP2D6.<p /><p>Language: en</p>",
language="en",
issn="0731-3810",
doi="",
url="http://dx.doi.org/"
}