@article{ref1,
title="Effect of alcohol on blood levels of branched-chain alpha-keto acids in male Wistar rats",
journal="Alcohol and alcoholism",
year="1991",
author="Dominicus, D. A. and Todoriki, H. and Ariizumi, M. and Akamatsu, T.",
volume="26",
number="5-6",
pages="597-603",
abstract="The effect of oral alcohol administration on branched-chain alpha-keto acids was studied in Wistar rats. Rats were divided into alcohol loading groups 1 (ethanol single daily dose: 2.5 g/kg body wt for 14 days) and 2 (ethanol dose: 5 g/kg body wt), and a pair-fed control group (isocaloric glucose and food equal to the amount taken by group 1 the previous day). Branched-chain alpha-keto acids, other alpha-keto acids and amino acids were analysed using high-performance liquid chromatography. Results showed a significant body weight increase in the alcohol loading groups. Concentrations of branched-chain amino acids and keto acids were significantly increased in the alcohol-treated groups. The blood levels of methionine, threonine, alanine and glutamic acid were also increased by alcohol administration. Blood levels of taurine and ornithine, however, showed a significant decrease in the alcohol-treated groups. These results show that alcohol increases the blood levels of branched-chain keto acids and branched-chain amino acids.<p /><p>Language: en</p>",
language="en",
issn="0735-0414",
doi="",
url="http://dx.doi.org/"
}