@article{ref1,
title="Clinical and physiological implications and correlations",
journal="Alcohol and alcoholism supplement",
year="1991",
author="Berglund, M.",
volume="1",
number="",
pages="399-402",
abstract="Cerebral dysfunction in alcoholics has important treatment implications. However, overall correlations between neuropathological impairment, neuropsychiatric performance, and clinical outcome are low and seldom reported to exceed 0.3-0.4. Three main diagnostic issues are discussed, reversibility of dementia symptoms, frontal lobe dysfunction, and the Wernicke-Korsakoff syndrome. To predict the reversibility of dementia symptoms in the individual alcoholic is important for the clinician. While routine diagnostic procedures do not give such information, a combination of brain imaging techniques and psychometric tests could be a possible development. Frontal lobe dysfunction is related to high-level cognition and general integration of behaviour. Psychometric tests give uncertain results. Inclusion of brain imaging techniques could possibly improve the diagnostic procedure. The autopsy frequency of the Wernicke-Korsakoff syndrome is much higher than the clinical diagnostic prevalence during life. This discrepancy may be related to the rarity of the classical symptoms and to overdiagnosis of non-Korsakoff alcohol dementia.<p /><p>Language: en</p>",
language="en",
issn="1358-6173",
doi="",
url="http://dx.doi.org/"
}