@article{ref1,
title="Alcohol abusers exhibit a higher IgA response to acetaldehyde-modified proteins",
journal="Alcohol and alcoholism supplement",
year="1991",
author="Worrall, S. and De Jersey, J. and Shanley, B. C. and Wilce, P. A.",
volume="1",
number="",
pages="261-264",
abstract="In the present study we have used an enzyme-linked immunosorbent assay to measure the immunoreactivity towards acetaldehyde-modified proteins in plasma from alcoholics, patients with non-alcoholic liver disease and control social drinkers. All three groups showed a response to modified proteins when total immunoglobulin binding was measured. However, when the assay was modified such that class-specific immunoglobulin binding was measured, it was found that the alcoholic response had a significantly greater immunoglobulin A component than patients with non-alcoholic liver disease or controls who were social drinkers. Thus measurement of IgA binding to acetaldehyde-modified proteins may be a marker for alcohol abuse.<p /><p>Language: en</p>",
language="en",
issn="1358-6173",
doi="",
url="http://dx.doi.org/"
}