@article{ref1,
title="Voluntary poisoning by Cortinarius orellanus: usefulness of an original early treatment after determination of orellanine in the biological fluids and tissues",
journal="Nephrologie",
year="1991",
author="Delpech, N. and Rapior, S. and Donnadieu, P. and Cozette, A. P. and Ortiz, J. P. and Huchard, G.",
volume="12",
number="2",
pages="63-66",
abstract="Cortinarius poisoning is generally caused by orellanine, a hydroxy bipyridine N, N-dioxide. This intoxication is characterized by acute nephritis which can lead to death without treatment. We reported a highly sensitive and simple fluorimetric technique to analyse orellanine by thin-layer chromatography on the basis of its characteristic photodecomposition into orelline. Using this procedure, we detected and assayed orellanine for the first time in plasma and renal biopsies of a woman who had deliberately ingested two fruit-bodies of Cortinarius orellanus. An early original treatment was carried out based on hemodialysis, combination plasmapheresis-hemoperfusion, and amino acids and diltiazem administration. These results indicate that it is now possible to make a precise diagnosis of orellanine poisoning.<p /><p>Language: fr</p>",
language="fr",
issn="0250-4960",
doi="",
url="http://dx.doi.org/"
}