@article{ref1,
title="Neuroleptic malignant syndrome: a complication of neuroleptics and cocaine abuse",
journal="Psychiatric quarterly",
year="1991",
author="Akpaffiong, M. J. and Ruiz, P.",
volume="62",
number="4",
pages="299-309",
abstract="One hundred and sixty psychiatric patients on Neuroleptics, with and without a history of substance abuse were daily monitored in order to establish the incidence of neuroleptic malignant syndrome in these two groups. Four (5.1%) of the cocaine abusers and none of the non-cocaine abusers developed neuroleptic malignant syndrome when treated with neuroleptics. Thus we argue that psychiatric patients with a history of cocaine abuse may be more at risk of developing neuroleptic malignant syndrome when treated with neuroleptics, possibly associated with the blockade of dopamine (D2-receptors) by neuroleptics and the activation of dopamine/5-HT receptors by cocaine-induced dopamine.<p /><p>Language: en</p>",
language="en",
issn="0033-2720",
doi="",
url="http://dx.doi.org/"
}