@article{ref1,
title="Studies on inhalation toxicity of 2-propanol",
journal="Drug and chemical toxicology",
year="1980",
author="Laham, S. and Potvin, M. and Schrader, K. and Marino, I.",
volume="3",
number="4",
pages="343-360",
abstract="Biological effects of a single exposure to moderate or high concentrations of 2-propanol were investigated in Sprague-Dawley rats. Acute toxicity (LC50, t:8 hours) of this widely used solvent was determined and found to be 19000 ppm (17380-20760 ppm) for females and 22500 ppm (19200-26400 ppm) for males. Determination of blood levels of 2-propanol and its metabolite, acetone, was carried out during and after a single 4-hour exposure (Concentration range: 500 to 8000 ppm). The amount of acetone and 2-propanol was directly related to the various air concentrations of alcohol inhaled. Increase of exposure time to 8 hours enhanced considerably the amount of blood acetone which could be determined even 20 hours after exposure. These findings indicate a slow conversion of this alcohol to acetone which can be used as biochemical indicator to exposure. Histopathological examination of rats exposed to high levels of 2-propanol shows typical lesions of chemical pneumonitis and pulmonary edema accompanied by foamy vacuolization of liver cells and severe focal cytoplasmic degradation.<p /><p>Language: en</p>",
language="en",
issn="0148-0545",
doi="10.3109/01480548009030125",
url="http://dx.doi.org/10.3109/01480548009030125"
}