@article{ref1,
title="Cocaine-induced hepatotoxicity: lipid peroxidation as a possible mechanism",
journal="Drug and chemical toxicology",
year="1984",
author="Teaf, C. M. and Freeman, R. W. and Harbison, R. D.",
volume="7",
number="4",
pages="383-396",
abstract="In vitro experiments with hepatic washed microsomal preparations showed that malondialdehyde (MDA) formation was increased in a time- and concentration-dependent manner using COC or NC as the substrate. Though 1 mM COC or NC inhibited MDA formation, significant elevations were observed for 100, 10 or 1 microM concentrations. NC at 10 microM after a 30 minute incubation produced a 34% decrease in hepatic microsomal cytochrome P450 whereas 1 mM NC had no such effect. MDA formation in vivo, measured as total absorbance at 535 nm per gram liver, was found to be maximal 4 hours after 40 mg/kg NC ip. Elevations of serum transaminase (SGPT) however were not found until 6 hours after NC. We conclude from these studies that COC and NC induce lipid peroxidation in the liver of PB-pretreated Swiss-origin mice and that peroxidative attack may be a mechanism for hepatotoxicity of these compounds.<p /><p>Language: en</p>",
language="en",
issn="0148-0545",
doi="10.3109/01480548408998265",
url="http://dx.doi.org/10.3109/01480548408998265"
}