@article{ref1,
title="Self-referential thinking, suicide, and function of the cortical midline structures and striatum in mood disorders: Possible implications for treatment studies of mindfulness-based interventions for bipolar depression",
journal="Depression research and treatment",
year="2012",
author="Marchand, William R.",
volume="2012",
number="online",
pages="246725-246725",
abstract="Bipolar depression is often refractory to treatment and is frequently associated with anxiety symptoms and elevated suicide risk. There is a great need for adjunctive psychotherapeutic interventions. Treatments with effectiveness for depressive and anxiety symptoms as well as suicide-related thoughts and behaviors would be particularly beneficial. Mindfulness-based interventions hold promise, and studies of these approaches for bipolar disorder are warranted. The aim of this paper is to provide a conceptual background for such studies by reviewing key findings from diverse lines of investigation. Results of that review indicate that cortical midline structures (CMS) appear to link abnormal self-referential thinking to emotional dysregulation in mood disorders. Furthermore, CMS and striatal dysfunction may play a role in the neuropathology underlying suicide-related thoughts and behaviors. Thus, combining studies of mindfulness interventions targeting abnormal self-referential thinking with functional imaging of CMS and striatal function may help delineate the neurobiological mechanisms of action of these treatments.<p /> <p>Language: en</p>",
language="en",
issn="2090-1321",
doi="10.1155/2012/246725",
url="http://dx.doi.org/10.1155/2012/246725"
}