@article{ref1,
title="No association of the tryptophan hydroxylase gene with bipolar affective disorder, unipolar affective disorder, or suicidal behaviour in major affective disorder",
journal="American journal of medical genetics",
year="1998",
author="Furlong, R. A. and Ho, L. and Rubinsztein, J. S. and Walsh, C. and Paykel, E. S. and Rubinsztein, D. C.",
volume="81",
number="3",
pages="245-247",
abstract="Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of 5-hydroxytryptamine (5-HT). An association study in bipolar affective disorder I or unipolar major affective disorder was performed by using a Bfa I restriction site polymorphism within intron 7 of the tryptophan hydroxylase gene. A total of 118 bipolar, 125 unipolar, and 437 control subjects were used in the study (1:3.7 bipolar:control, 1:3.5 unipolar:control). There were no significant differences in TPH allele or genotype frequencies between the affective disorder and control groups. In addition, bipolar and/or unipolar subjects with or without a history of suicide attempts were compared for the TPH polymorphism. No significant differences were found between suicidal and non-suicidal groups in major affective disorder, in contrast to a previous study suggesting an association of this polymorphism with a history of suicide attempts among alcoholic violent offenders.<p /><p>Language: en</p>",
language="en",
issn="0148-7299",
doi="",
url="http://dx.doi.org/"
}