@article{ref1,
title="Studies on the evaluation of the toxicity of various salts of lead, manganese, platinum, and palladium",
journal="Environmental health perspectives",
year="1975",
author="Holbrook, D. J. and Washington, M. E. and Leake, H. B. and Brubaker, P. E.",
volume="10",
number="",
pages="95-101",
abstract="Preliminary studies have been conducted on various parameters in order to assess the possible and relative toxicities of a number of metallic salts. Upon oral administration in lethal-dose experiments, two soluble Pt4+ salts were more toxic than the other salts tested. Following intraperiotneal injection in lethal-dose experiments, PbCl2 was less toxic than several of the soluble or partially soluble salts of Pt4+, Pd2+, and Mn2+. An intake of a total of approximately 250 mg of Pt4+ per rat in the drinking fluid over a 30-day interval did not affect the activities of aniline hydroxylase and aminopyrine demethylase in rat liver microsomes. In rats receiving soluble Pt4+ salts in the drinking fluid, the highest concentration of Pt was found in the kidney and an appreciiable concentration was found in the liver.<p /><p>Language: en</p>",
language="en",
issn="0091-6765",
doi="",
url="http://dx.doi.org/"
}