@article{ref1,
title="What does the corpus callosum tell us about brain changes in the elderly?",
journal="Expert review of neurotherapeutics",
year="2011",
author="Di Paola, Margherita and Caltagirone, Carlo and Spalletta, Gianfranco",
volume="11",
number="11",
pages="1557-1560",
abstract="Evaluation of: Ryberg C, Rostrup E, Paulson OB et al. On behalf of the LADIS study group. Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: a 3 year follow-up of the LADIS study cohort. J. Neurol. Sci. 307(1-2), 100-105 (2011). The corpus callosum is the largest hemispheric interconnection bundle in the human brain. Its anterior-posterior fiber caliber gradient can help in understanding the pathophysiological mechanisms underlying white matter changes both in old age and dementia. Here, the Leukoaraiosis and Disability (LADIS) study, a longitudinal cohort study, which shows an association between corpus callosum atrophy and cognitive and motor decline in the elderly, provides the possibility to consider the use of multimodal macro-microstructural imaging of corpus callosum as a marker of structural brain changes of physiological and pathological aging.<p /><p>Language: en</p>",
language="en",
issn="1473-7175",
doi="10.1586/ern.11.130",
url="http://dx.doi.org/10.1586/ern.11.130"
}