@article{ref1,
title="A novel toxic alkaloid from poison hemlock (Conium maculatum L., Apiaceae): Identification, synthesis and antinociceptive activity",
journal="Food and chemical toxicology",
year="2012",
author="Radulović, Niko and Dorđević, Nevenka and Denić, Marija and Pinheiro, Mariana Martins Gomes and Fernandes, Patricia Dias and Boylan, Fabio",
volume="50",
number="2",
pages="274-279",
abstract="2-Pentylpiperidine, named conmaculatin, a novel volatile alkaloid related to coniine was identified from the renowned toxic weed Conium maculatum L. (Apiaceae). The structure of conmaculatin was corroborated by synthesis (8 steps starting from cyclohexanol, overall yield 12%). Conmaculatin's strong peripheral and central antinociceptive activity in mice was observed in a narrow dose range (10-20mg/kg). It was found to be lethal in doses higher than 20mg/kg.<p /><p>Language: en</p>",
language="en",
issn="0278-6915",
doi="10.1016/j.fct.2011.10.060",
url="http://dx.doi.org/10.1016/j.fct.2011.10.060"
}